Benzema was substituted with a suspected hamstring problem in the first half of Al-Ittihad’s match against Al-Wehda on Monday.
The French striker went down in the first half of the Arabian Pro League match and was treated on the pitch. It was decided the 35-year-old could no longer continue and he left, with summer signing Jota taking his place after 42 minutes.
Benzema and Al-Ittihad will be hoping the injury is not serious as the player is a key figure for the Saudi champions.
The former Real Madrid forward has scored one goal and set up two more for the club since joining on a free transfer in the summer.